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DNA Engineered Noble Metal Nanoparticles

Fundamentals and State-of-the-Art Nanobiotechnology
By Ignác Capek
Series: Advanced Materials Series
Copyright: 2015   |   Status: Published
ISBN: 9781118072141  |  Hardcover  |  
668 pages | 183 illustrations
Price: $225 USD
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Academic and industrial researchers, postgraduate students (MSc and PhD), technologists and engineers in nanoscience and metal fluids, fine and specialty chemicals industries, materials scientists, colloid chemists, bioengineers and those involved in R&D for smart nanomaterials, nanomedicine and sensors.

There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and, therefore, they are attractive materials for nanotechnology in biochemistry and medicine.
In this book, the author reviews work performed dealing with the DNA structure and functionalities, interactions between DN noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA’s chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, the book reviews recent progress in the area of DNA-noble metal nanoparticles-based artificial nanostructures. The preparation, collective properties, and applications of various DNA-based nanostructures are also described.

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Author / Editor Details
Ignác Capek was appointed Head of the Department at the Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia, lecturer in the Faculty of Industrial Technologies, Trenčín University, Púchov and Principal of MSc and PhD studies. He is the principle investigator of more than 20 basic research and industrial projects. He is author and co-author of 3 scientific books and 20 chapters, 20 review articles, and about 200 scientific articles as well as more than 20 patents. He spent several long-term visits as a postdoc and visiting professor at foreign universities and scientific institutes in Canada, Germany, Japan, Taiwan and France.

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Table of Contents
1 Introduction
2 Nucleic Acids
2.1 DNA/RNA Basics
2.2 Aptamers, Telomers and Oligonucleotides
2.3 Techniques and Approaches
2.4 DNA-Based Molecular Nanomachines
2.5 Peptide Nucleic Acid
2.6 Nanobiotechnology
3 Noble Metal Nanoparticles
3.1 Preparation and Modification
3.2 Optical and Physical Properties
3.3 Conjugates
4 DNA-Based Conjugates
4.1 General
4.2 Condensation
4.3 Conjugates
5 DNA-Noble Metal Nanoparticle Conjugates
5.1 General Approaches
5.2 DNA Monomers and Oligomers
5.2.1 Gold Nanoparticles
5.2.2 Silver Nanoparticles
5.3 Hybridization and Denaturation
5.4 DNA Biotemplates
6 DNA-Gold Nanoparticle Conjugates
6.1 DNA-Gold Zero-Dimensional Nanoparticle Conjugates
6.2 DNA One-Dimensional Gold Nanoparticle Conjugates
7 PNA-Noble Metal Nanoparticles Conjugates
7.1 PNA-Gold Nanoparticle Conjugates
7.2 PNA-Silver Nanoparticle Conjugates
8 DNA-Silver Nanoparticles Conjugates
9 The Structure of DNA-Noble Metal Nanoparticles Conjugates
9.1 Configuration of DNA-Noble Metal
Nanoparticles Conjugates
9.2 Stabilization of DNA Conjugates
9.3 Nanostructures and Nanoconstructs
9.4 Colorimetric and Sensing Assays
10 Photochemical and Photophysical Events
10.1 Noble Metal Nanoparticles
10.2 DNA Nucleobases
10.3 DNA/PNA
10.4 DNA-Dyes Conjugates
10.5 DNA-AuNP-Dye Conjugates
10.6 DNA-Gold Nanoparticle Conjugates
10.7 DNA-AgNPs
10.8 Hot Gold Nanoparticles
11 Nanoparticle Therapeutics
11.1 Biodecorated Nanoparticle-Based Therapies
11.2 Photothermal Therapy
11.3 Cells
11.4 Gene Therapy
11.5 Blood Fluid Effect
11.6 Other Application Approaches
12 Conclusion
DNA Entities
Vocabulary and Definitions

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Author/Editor Details
Table of Contents
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