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DNA Engineered Noble Metal Nanoparticles

Fundamentals and State-of-the-Art of Nanobiotechnology
By Ignac Capek
Series: Advanced Materials Series
Copyright: 2015   |   Status: Published
ISBN: 9781118072141  |  Hardcover  |  
668 pages
Price: $225.00 USD
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One Line Description
This unique, comprehensive and interdisciplinary book covers the broad area of DNA and noble metal nanoparticles nanostructures and their current and emerging bio-applications.

Academic and industrial researchers, postgraduate students (MSc and PhD), technologists and engineers in nanoscience and metal fluids, fine and specialty chemicals industries, materials scientists, colloid chemists, bioengineers and those involved in R&D for smart nanomaterials, nanomedicine and sensors.

There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and, therefore, they are attractive materials for nanotechnology in biochemistry and medicine.

In this book, the author reviews work performed dealing with the DNA structure and functionalities, interactions between DN noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA’s chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, the book reviews recent progress in the area of DNA-noble metal nanoparticles-based artificial nanostructures. The preparation, collective properties, and applications of various DNA-based nanostructures are also described.

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Author / Editor Details
Ignác Capek was appointed Head of the Department at the Polymer Institute, Slovak Academy of Sciences, Bratislava, Slovakia, lecturer in the Faculty of Industrial Technologies, Trenčín University, Púchov and Principal of MSc and PhD studies. He is the principle investigator of more than 20 basic research and industrial projects. He is author and co-author of 3 scientific books and 20 chapters, 20 review articles, and about 200 scientific articles as well as more than 20 patents. He spent several long-time visits as postdocs and visiting professor at the foreign universities and scientific institutes in abroad (Canada, Germany, Japan, Taiwan and France).

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