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Integrated Materials for Biomedical Technology

Edited by Murugan Ramalingam, Ashutosh Tiwari, Seeram Ramakrishna, and Hisatoshi Kobayashi
Series: Biomedical Science, Engineering, and Technology
Copyright: 2012   |   Status: Published
ISBN: 9781118423851  |  Hardcover  |  
432 pages | 126 illustrations
Price: $195 USD
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One Line Description
Provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications.

The book is intended for a wide audience including students, researchers, professors, and industrial experts working in the fields of biomaterials, materials science and engineering, nanoscience and nanotechnology, bioengineering, biomedical sciences, and tissue engineering.

This cutting edge book provides all the important aspects dealing with the basic science involved in materials in biomedical technology, especially structure and properties, techniques and technological innovations in material processing and characterizations, as well as the applications. The volume consists of 12 chapters written by acknowledged experts of the biomaterials field and covers a wide range of topics and applications including:
• The different types of nanobiomaterials
• How to generate porous biomaterials for tissue engineering
•Calcium phosphate-based biomaterials intended for mineralized tissue regenerative applications
• Nanocrystalline form of calcium phosphates
• Design and fabrication of SiO2 nanoparticles
• New kinds of titanium alloy implants
• Injectable growth factor system based on bone morphogenetic proteins
• Impedance sensing of biological processes in mammalian cells
• Hydrogels-based implantable glucose sensors
• Molecular design of multifunctional polymers for gene transfection
• Hydrogels and their potential biomedical applications
• Hybrid biomaterials with high mechanical and biological properties

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Author / Editor Details
Murugan Ramalingam is an associate professor of Biomaterials and Tissue Engineering at the Institut National de la Santé et de la Recherche Médicale U977, Faculté de Chirurgie Dentaire, Université de Strasbourg (UdS), France. Concurrently he holds an Adjunct Associate Professorship at the Tohoku University, Japan.

Ashutosh Tiwari is an Assistant Professor of nanobioelectronics at Biosensors and Bioelectronics Centre, IFM-Linköping University, Sweden, as well as Editor-in-Chief of Advanced Materials Letters.

Seeram Ramakrishna, FREng, FNAE, FAIMBE is the Director of HEM Labs at the National University of Singapore. He has authored five books and over 400 international journal papers, which garnered more than 14,000 citations.

Hisatoshi Kobayashi is a group leader of WPI Research center MANA, National Institute for Material Science, Tsukuba Japan. He is currently the President of International Association of Advanced Materials.

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Table of Contents
Preface 1. 1D~3D Nano-engineered Biomaterials for Biomedical Applications 1: Hui Chen, Xiaokang Li and Yanan Du 1.1 Introduction. 1.2 3D Nanomaterials Towards Biomedical Applications. 1.2.1 Synthesis of NPs 3. 1.2.2 Synthesis in Water. 1.2.3 Synthesis in Organic Medium. 1.2.4 Other Methods. 1.3 Structural and Functional Modification. 1.3.1 Surface Modification. 1.3.2 Internal Modification. 1.4 Properties of Nanoparticles for Biomedical Application. 1.4.1 Toxicity. 1.4.2 Optical Properties. 1.5 Applications of NPs. 1.5.1 Biomedical Imaging. 1.5.2 Analytical Tools. 1.5.3 Therapeutic Biomedicine. 1.5.4 Drug Delivery. 1.6 2D Nanomaterials Towards Biomedical Applications. 1.6.1 Materials of Nanofiber. 1.6.2 Fabrication Strategies. 1.6.3 Biomedical Applications of 2D Nanomaterials. 1.7 1D Nanomaterial Towards Biomedical Applications. 1.7.1 Fabrication Strategies. 1.7.2 Micromechanical Characterization. 1.7.3 Applications Toward Biomedical Field. 1.8 Conclusion. References. 2. Porous Biomaterials: Nasim Annabi. 2.1 Introduction. 2.2 Porosity and Pore Architecture of Biomaterial Scaffolds. 2.3 Methods to Measure Porosity and Pore Size. 2.4 Porosity Generation Techniques. 2.4.1 Solvent Casting/particle Leaching. 2.4.2 Phase Separation. 2.4.3 Freeze Drying. 2.4.4 Electrospinning. 2.4.5 Gas-based Techniques. 2.5 Summary. References. 3. Bioactive and Biocompatible Polymeric Composites Based on Amorphous Calcium Phosphate: Joseph M. Antonucci and Drago Skrtic. 3.1 Introduction. 3.2 Experimental Approach. 3.3 Results and Discussion. 3.4 Concluding Remarks/Future Directions. Acknowledgements. References. Appendix 1. List of Acronyms used Throughout the Proposal. 4. Calcium Phosphates and Nanocrystalline Apatites for Medical Applications: Sunita Prem Victor and Chandra P. Sharma. 4.1 Introduction. 4.2 Chemistry of Calcium Phosphates. 4.3 Nanocrystalline Calcium Phosphates. 4.4 Properties of Calcium Orthophosphates. 4.4.1 Mechanical Properties. 4.4.2 Electrical Properties. 4.4.3 Porosity. 4.4.4 Biological Properties. 4.5 Biomedical Applications of Calcium Phosphates. 4.5.1 Bone Cements. 4.5.2 Carrier and Delivery Systems. 4.5.3 Coatings. 4.5.4 Scaffolds. 4.6 Conclusion. References. 5. SiO2 Particles with Functional Nanocrystals: Design and Fabrication for Biomedical Applications: Ping Yang. 5.1 Introduction. 5.1.1 Nanocrystals. 5.1.2 NCs Encapsulated in SiO2 Particles. 5.1.3 Bioapplications of SiO2 Particles with Colloidal NCs. 5.1.4 Scope. 5.2 Fabrication Methods of SiO2 Particles with NCs. 5.2.1 SiO2 Particles with Luminescent NCs. 5.2.2 SiO2 Particles with Magnetic NCs. 5.2.3 SiO2 Particles with Noble Metallic NCs. 5.2.4 SiO2 Particles with Multifunctional NCs. 5.3 Main Research Results for SiO2 Particles with NCs. 5.3.1 SiO2 Particles with Luminescent QDs. 5.3.2 SiO2 Particles with Magnetic NCs. 5.3.3 SiO2 Particles with Noble Metallic NCs. 5.3.4 SiO2 Particles with Mutifunational NCs. 5.4 Multifunctional SiO2 Particles for Biomedical Applications. 5.4.1 Surface Modification and Conjugation of Luminescent SiO2 Particles. 5.4.2 Magnetic SiO2 Particles for Highly Efficient Adsorption of Drugs. 5.4.3 Plasmonic SiO2 Particles as Surface-enhanced Raman Scattering. 5.5 Conclusions and Outlook. Acknowledgements. References. 6. New Kind of Titanium Alloys for Biomedical Application: Yufeng Zheng, Binbin Zhang, Benli Wang and Li Li. 6.1 Introduction. 6.2 Dental Cast Titanium Alloys. 6.3 Low Modulus Titanium Alloys. 6.4 Nickel Free Shape Memory Titanium Alloys. 6.5 Summary. References. 7. BMP-based Bone Tissue Engineering: Ziyad S. Haidar and Murugan Ramalingam. 7.1 Introduction. 7.2 Challenges in Protein Therapy. 7.3 BMP Delivery Requirements. 7.4 BMP-specific Carrier Types and Materials. 7.5 Summary. Acknowledgements. References. 8. Impedance Sensing of Biological Processes in Mammalian Cells: Lamya Ghenim, Hirokazu Kaji, Matsuhiko Nishizawa and Xavier Gidrol. 8.1 Introduction. 8.2 Cell Attachment and Spreading Processes. 8.3 Cell Motility. 8.4 Apoptosis. 8.5 Mitosis. 8.6 Single Cell Analysis. 8.7 Conclusion. References. 9. Hydrogel Microbeads for Implantable Glucose Sensors: Jung Heo and Shoji Takeuchi. 9.1 Introduction. 9.2 Fabrication Methods of Hydrogel Microbeads. 9.2.1 Micromolding. 9.2.2 Lithography. 9.2.3 Droplet-based Microbeads Synthesis Using Microfluidic Devices. 9.3 Fluorescence-based Glucose Monitoring. 9.3.1 Glucose-binding Proteins. 9.3.2 Boronic Acid. 9.4 Biocompatibility.9.4.1 Inflammation. 9.4.2 Enhancement of Biocompatibility. 9.5 Summary. References. 10. Molecular Design of Multifunctional Polymers for Gene Transfection: Chao Lin, Bo Lou and Rong Jin. 10.1 Introduction. 10.2 Barriers to Non-viral Gene Delivery. 10.3 Molecular Design of Polymer Vectors for Efficient Gene Delivery. 10.3.1 Serumstable Polymer Vectors. 10.3.2 Polymer Vectors for Targeted Gene Delivery. 10.3.3 Polymer Vectors for Efficient Cellular Uptake. 10.3.4 Polymer Vectors for Endosomal Escape. 10.3.5 Polymer Vectors for Nuclear Targeting. 10.3.6 Polymer Vectors for Vector Unpacking. 10.4 Molecular Design of Polymer Vectors with Low Cytotoxicity. 10.4.1 Low-toxic Polymer Vectors via Chemical Modification. 10.4.2 Hydrolysable Polymer Vectors. 10.4.3 Bioreducible Polymer Vectors. 10.5 Summary. Acknowledgements. Appendix: List of Abbreviations. References. 11. Injectable in situ Gelling Hydrogels as Biomaterials: Hardeep Singh and Lakshmi S. Nair. 11.1 Introduction. 11.1.1 Different Types of Hydrogels. 11.2 Injectable in situ Gelling Hydrogels. 11.3 Clinical Applications of Hydrogels. 11.4 Injectable Hydrogels for Biomedical Applications. 11.4.1 Poly(hydroxyethyl methacrylic) acid (p-HEMA). 11.4.2 Polyacrylamide Hydrogels. 11.4.3 Poly(vinyl alcohol) Hydrogels. 11.4.4 Poly(ethylene glycol) Hydrogels. 11.4.5 Collagen and Gelatin. 11.4.6 Hyaluronic Acid Hydrogels. 11.4.7 Chitosan Hydrogels. 11.4.8 Hyaluronic Acid-Chitosan Based Injectable Hydrogels for Cartilage Regeneration. 11.5 Conclusions. References. 12. Metal-polymer Hybrid Biomaterials with High Mechanical and Biological Compatibilities: Masaaki Nakai and Mitsuo Niinomi. 12.1 Introduction. 12.2 Fabrication Methods of Porous Titanium Filled with Medical Polymer. 12.3 Mechanical Properties of Porous Titanium Filled with Medical Polymer. 12.4 Biological Properties of Porous Titanium Filled with Medical Polymer. 12.5 Summary. References. Index.

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TEC059000: Technology & Engineering/Biomedical
SCI010000: Science/Biotechnology
TEC021000: Technology & Engineering/Materials Science
MQW: Biomedical Engineering
TCB: Biotechnology
TGM: Materials Science

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